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美国明尼苏达代写论文:受控释放
2018-01-20 23:58
受控释放指的是一种药物通过一种装置来控制药物的传递,这种控制的目的是在特定的时间内以特定的速度将药物以特定的速度传递给独立于当地环境的药物。控释制剂还可在活性部位加入促进药物定位的方法。站点特定和目标交付系统是用来表示这种类型的控制的描述术语。交付期要比持续释放的时间长得多,而且可能会随时间的变化而变化。控制释放机制的目的是根据可预测的速率在体内释放药物,可以通过体外测量得到验证。控制释药技术意味着对药物可用性的物理化学机制的了解程度,达到可指定的剂型释放率的程度。潜在的开发和口服药物释放系统的新方法,胃内漂浮药片,Tran的黏膜片和微孔膜涂层片。应用于控释技术到剂型设计的一个例子是一个聚合物基体,其中含药溶液以微细胞的形式分散。分散溶液中的屏障渗透性和药物溶解度是可调节的变量,可提供可预测的药物释放率。美国明尼苏达代写论文:受控释放
Controlled release implies regulation of the delivery of a a drug by a device the control is aimed at delivering the drug at a specific rate for a definite period of time independent of the local environments. Controlled release may also incorporate methods of promote localization of drug at an active site. Site specific and targeted delivery systems are the descriptive term used to denote this type of control. The periods of delivery are much longer than in case of sustained release and may vary from days to years. Controlled release mechanism is designed to release the drug in vivo according to predictable rates that can be verified by in-vitro measurements. Controlled release technology implies a quantities understanding of the physic chemical mechanism of drug availability to the extent that the dosage form release rate can be specified. Potential development s and new approaches to oral controlled release drug delivery systems, intragastric floating tablets, Tran's mucosal tablets and micro porous membrane coated tablets . An example of application to the controlled release technology to dosage form design consists of a polymer matrix in which a drug containing solution is dispersed in the form of micro cells. The barrier permeability and the drug solubility in the dispersed solution are variables that can be adjusted to provide predictable drug release rates.
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